Periapikal og endodontisk status i det permanente tandsæt hos patienter med hypofosfatæmisk rakitis
Introduktion – Hypofosfatæmisk rakitis (HR) er en sjælden, arvelig sygdom, hvor der ofte er rapporteret spontan apikal parodontitis. De fleste tidligere rapporter er imidlertid baseret på relativt små patientmaterialer og publiceret, inden sygdommen kunne verificeres genetisk eller biokemisk. Formålet med denne undersøgelse var at beskrive de periapikale og endodontiske forhold hos patienter med genetisk og/eller biokemisk verificeret HR. Materiale og metoder – De patienter, der indgår i denne undersøgelse, blev rekrutteret gennem et stort medicinsk studium af HR i Danmark og gennemgik en klinisk-radiologisk-odontologisk undersøgelse. I denne artikel rapporteres de endodontiske og periapikale fund fra den radiologiske undersøgelse. Resultater – I alt 52 patienter i alderen fra 5,7 til 74,5 år indgik i undersøgelsen. Patienterne havde et stort antal tænder med endodontisk behandling og/eller periapikale patologiske forhold. Antal afficerede tænder steg med alderen, medens der ikke kunne påvises nogen statistisk signifikant association med køn. I den yngste aldersgruppe var det udelukkende incisiver og hjørnetænder, der var afficeret, medens præmolarer og molarer udgjorde en relativt større andel af de afficerede tænder i de ældre aldersgrupper. Konklusion – Endodontisk behandling og periapikale problemer er hyppigt forekommende hos HR-patienter, og antallet af afficerede tænder stiger med alderen. Behovet for endodontisk behandling hos denne patientgruppe er stort.
Klinisk relevans:
Periapical and endodontic status in the permanent dentition in patients with rickets
Objective – Hypophosphatemic rickets (HR) is a rare hereditary disease in which spontaneous periapical infections are frequently reported. Most previous reports have been based on a small number of HR patients and have been published before the disease could be confirmed genetically. The aim of the present study was to describe the periapical and endodontic status of permanent teeth in patients with genetically and/or biochemically confirmed HR. Study design – The patients were recruited from a medical study of HR patients, and underwent a dental examination including a digital panoramic radiograph, which was scored for teeth with periapical radiolucencies and/or endodontic treatment. Results – A total of 52 patients (age range: 5.7 to 74.5 yrs; 17 males and 35 females) were included. HR patients were characterized by a high number of endodontically affected teeth. The number of affected teeth rose significantly with age, while no statistically significant gender difference was found. In the youngest age group, only incisors and canines were affected, while the relative proportion of affected premolars and molars increased with age. Conclusions – Endodontically affected teeth are common in HR patients, and the number of affected teeth increased significantly with age. Hence, endodontic treatment among HR patients will be needed in many – perhaps more than previous thought.
