VESICULO-BULLOUS ORAL MUCOSAL LESIONS
Blistering in the oral mucosa may occur due to different reasons. The most frequent cause of blistering in the oral mucosa is viral infections, including herpes simplex and Varicella-Zoster virus infections. Here, the blisters primarily present as vesicles, fluid accumulations of less than 5 mm that appear in clusters. Blisters in the oral mucosa can also be caused by specific autoimmune diseases, mainly pemphigus vulgaris and pemphigoid. The blisters are characterized as bullae, which bursts easily and leave behind an eroded mucous membrane, which is covered by fibrin. A blistering oral mucosal disease is often associated with pain and discomfort. In this article, the most common diseases giving rise to blistering in the oral mucosa are reviewed.